The APC protein is pivotal in controlling the Wnt signaling pathway, which is essential for cell proliferation and differentiation. By regulating this pathway, the APC protein ensures that cells do not divide uncontrollably. It binds to beta-catenin, a key protein in the Wnt pathway, marking it for degradation and thus preventing excessive cellular proliferation. When the APC gene functions correctly, it helps maintain the integrity of tissues and prevents the development of tumors.
