How Does the UPS Interact with Other Cancer Pathways?
The UPS does not operate in isolation but rather interacts with numerous other cellular pathways. For example, it is closely linked with the autophagy-lysosome pathway, which also mediates protein degradation. Cancer cells may utilize both systems to escape therapy-induced stress, suggesting that dual inhibition of the UPS and autophagy could be an effective strategy. Moreover, the UPS is involved in regulating the stability of transcription factors like MYC and Cyclin D1, further highlighting its broad impact on cellular processes pivotal to cancer development.
