The effectiveness of locoregional therapy varies depending on the type and stage of cancer, as well as the specific treatment modalities used. For instance, breast-conserving surgery followed by radiation therapy has been shown to be as effective as mastectomy for early-stage breast cancer. Similarly, high-dose regional chemotherapy can be very effective for certain types of abdominal cancers. Ongoing research continues to refine these therapies, making them more effective and less toxic.