The Vogelstein model has profoundly influenced cancer research by emphasizing the role of specific genetic mutations in cancer progression. It has led to the development of targeted therapies aimed at these genetic alterations. For example, understanding the role of KRAS mutations has paved the way for developing inhibitors that specifically target mutant KRAS proteins. Additionally, the model has influenced the design of screening programs aimed at early detection of cancers, particularly colorectal cancer.
