Acquired resistance can be detected through various methods:
- Biopsy and Genomic Sequencing: Analyzing tumor samples before and after treatment can reveal genetic and epigenetic changes associated with resistance.
- Liquid Biopsies: Sampling circulating tumor DNA (ctDNA) from blood can provide real-time insights into the genetic landscape of the cancer and emerging resistance mechanisms.
- Functional Assays: Laboratory tests on cancer cells can help determine changes in drug sensitivity and identify underlying mechanisms of resistance.
