The diagnosis of acromegaly typically involves a combination of clinical evaluation, imaging studies, and laboratory tests. A key diagnostic test is the measurement of IGF-1 levels in the blood, which are elevated in individuals with acromegaly. An oral glucose tolerance test (OGTT) may also be performed to assess GH levels. Imaging studies, such as MRI, can help identify pituitary adenomas, which are often the underlying cause of acromegaly.