Diagnosing CUP can be complex. It typically involves a series of steps including:
1. Biopsy: A tissue sample is taken from the cancerous area and examined under a microscope. 2. Imaging Tests: Techniques such as CT scans, MRI, and PET scans are used to look for the primary site. 3. Laboratory Tests: Blood tests and molecular profiling can help in identifying characteristics of the cancer cells. 4. Histopathology: The microscopic examination of tissue to study the manifestations of disease.