How is Genomic Imprinting Studied in Cancer Research?
Genomic imprinting in cancer is studied using a combination of genetic, epigenetic, and genomic approaches. Techniques such as bisulfite sequencing and methylation-specific PCR are employed to analyze DNA methylation patterns. High-throughput methods like RNA sequencing and ChIP sequencing help identify changes in gene expression and histone modifications. Additionally, animal models and cell lines with specific imprinting disruptions are used to study the functional consequences of these changes.
