Several techniques are used to measure intratumor heterogeneity:
- Single-cell sequencing: This method allows for the analysis of genetic material at the individual cell level, providing deep insights into the genetic diversity within a tumor. - Multiregional sequencing: By analyzing multiple regions of a tumor, this technique can identify spatial variations in genetic alterations. - Immunohistochemistry: This approach uses antibodies to detect specific proteins in tissue samples, revealing phenotypic diversity among cancer cells.
