Diagnosis of PSTT typically involves a combination of clinical evaluation, imaging studies, and laboratory tests. A pelvic exam and an ultrasound are usually the first steps. Blood tests measuring levels of human chorionic gonadotropin (hCG) are also conducted, although hCG levels in PSTT are often lower than in other trophoblastic diseases. A definitive diagnosis usually requires a biopsy of the tumor tissue, which is examined under a microscope by a pathologist.
