Several factors contribute to reproducibility issues in cancer research:
Methodological Variability: Differences in experimental protocols, sample handling, and data analysis can lead to inconsistent results. Biological Variability: Inherent differences in biological systems, such as genetic diversity among cancer cells, can cause variability in outcomes. Data Transparency: Lack of access to raw data and detailed methodologies can hinder replication efforts. Publication Bias: Studies with positive results are more likely to be published, while negative or null results are often neglected, skewing the scientific literature. Small Sample Sizes: Studies with small sample sizes may not be representative and can produce results that are not generalizable.
