What are Potential Therapeutic Strategies Targeting the TME?
Therapeutic strategies targeting the TME aim to disrupt the supportive interactions between cancer cells and their microenvironment. These strategies include:
Inhibition of CAF activity to reduce their pro-tumorigenic effects. Modulation of immune cell populations to enhance anti-tumor immunity. Targeting angiogenesis to disrupt the blood supply to tumors. Normalizing the ECM to reduce its supportive role in cancer progression.
By targeting these components, researchers hope to improve treatment outcomes and overcome resistance mechanisms.
