Targeting invasion and metastasis involves disrupting key pathways and molecules:
1. MMP inhibitors: These prevent the degradation of the ECM, hindering invasion. 2. EMT inhibitors: Blocking EMT can reduce the motility of cancer cells. 3. Immune checkpoint inhibitors: Enhancing the immune response can help eliminate circulating tumor cells. 4. Metastasis suppressors: Molecules like NM23 and KISS1 that inhibit metastatic spread are being explored as therapeutic targets.
