What are Some Challenges in Combination Therapy Trials?
Despite the potential benefits, combination therapy trials face several challenges: - Toxicity: Combining multiple drugs can increase the risk of adverse effects, making it crucial to find a balance between efficacy and safety. - Complexity: The interactions between different drugs can be complex, requiring sophisticated models and analytical methods to understand and predict outcomes. - Regulatory Hurdles: Obtaining approval from regulatory bodies can be more complicated for combination therapies, as it involves multiple agents that may have different mechanisms of action and side effect profiles.
