Several genes are frequently mutated in various cancers, and these mutations often serve as driver mutations. Some of the most well-known include:
- TP53: Mutations in this tumor suppressor gene are found in over 50% of all cancers. - KRAS: Commonly mutated in pancreatic, colorectal, and lung cancers. - EGFR: Mutations in this gene are often seen in non-small cell lung cancer. - PIK3CA: Frequently mutated in breast and endometrial cancers. - BRAF: Mutations in this gene are common in melanoma and thyroid cancer.
