What Are Some Common Genetic Disorders Associated with Cancer?
Several genetic disorders are strongly associated with an increased risk of developing cancer. Some of these include:
- BRCA1 and BRCA2 mutations: These mutations significantly increase the risk of breast and ovarian cancers. - Lynch syndrome (Hereditary Non-Polyposis Colorectal Cancer): This is associated with a higher risk of colorectal and several other cancers. - Li-Fraumeni syndrome: Caused by mutations in the TP53 gene, this syndrome increases the risk of various cancers, including sarcomas, breast cancer, and brain tumors. - Familial Adenomatous Polyposis (FAP): This condition, caused by mutations in the APC gene, leads to numerous colon polyps and a high risk of colorectal cancer.
