What Are Some Examples of Cancers Associated with Defective DNA Repair?
Various types of cancer are linked to defective DNA repair mechanisms. These include:
- Breast Cancer: Often associated with mutations in BRCA1 and BRCA2. - Ovarian Cancer: Also linked to BRCA1 and BRCA2 mutations. - Colorectal Cancer: Frequently involves defects in mismatch repair genes like MLH1 and MSH2. - Lung Cancer: Can be associated with defects in NER pathways.
