defective dna repair

What Are Some Key DNA Repair Mechanisms?

There are several key DNA repair mechanisms, including:
Base Excision Repair (BER): Repairs small, non-helix-distorting base lesions.
Nucleotide Excision Repair (NER): Removes bulky, helix-distorting lesions like thymine dimers.
Mismatch Repair (MMR): Corrects mismatched nucleotides that can result from DNA replication errors.
Homologous Recombination (HR): Repairs double-strand breaks using a homologous template.
Non-Homologous End Joining (NHEJ): Repairs double-strand breaks without the need for a homologous template.

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