Several GAPs have been implicated in cancer, including:
Neurofibromin 1 (NF1): Acts as a Ras-GAP and its loss-of-function mutations are linked to neurofibromatosis and various cancers. p120GAP: Another Ras-GAP that is often downregulated in cancers, leading to sustained Ras signaling. RhoGAPs: Regulate Rho GTPases and are involved in controlling cell migration, invasion, and metastasis.
