What are Some Notable Studies and Clinical Trials?
Several studies and clinical trials have demonstrated the potential of CRISPR in cancer treatment. For example:
1. CRISPR-Cas9 in T Cells: Researchers have used CRISPR to edit T cells, enhancing their ability to attack cancer cells. Early-phase clinical trials are exploring the safety and efficacy of these modified T cells in treating cancers such as melanoma and certain types of leukemia. 2. P53 Gene Editing: The p53 gene, often referred to as the "guardian of the genome," is frequently mutated in cancers. Studies have used CRISPR to correct these mutations, potentially restoring the gene's tumor-suppressing functions. 3. Synthetic Lethality: Some research focuses on exploiting synthetic lethality, where two genes are simultaneously targeted. If one gene is already mutated in cancer cells, CRISPR can be used to knock out the second gene, leading to cell death and providing a new avenue for cancer therapy.
