What are Some Notable Studies Utilizing scRNA-seq in Cancer?
Several landmark studies have leveraged scRNA-seq to make significant advances in cancer research:
Triple-Negative Breast Cancer: Researchers used scRNA-seq to identify distinct cell subpopulations with unique gene expression profiles, shedding light on the heterogeneity of this aggressive cancer type. Glioblastoma: scRNA-seq revealed the presence of multiple cell states within glioblastomas, providing insights into their evolutionary trajectories and potential therapeutic targets. Melanoma: By profiling tumor-infiltrating lymphocytes, scRNA-seq studies have identified specific immune cell subsets associated with better responses to checkpoint inhibitors.
