What are Some of the STAT3 Inhibitors in Development?
Several STAT3 inhibitors are currently under preclinical and clinical investigation. Examples include:
Stattic: A small molecule inhibitor that selectively inhibits the activation and dimerization of STAT3. BP-1-102: Another small molecule that targets the SH2 domain of STAT3, preventing its phosphorylation and activation. OPB-31121: An orally administered inhibitor that has shown anticancer activity in various models. AZD1480: A JAK2 inhibitor that indirectly inhibits STAT3 by blocking its upstream activator.
