What Are the Advantages of SERDs Over Other Therapies?
SERDs offer several advantages over other endocrine therapies:
1. Complete ER Degradation: Unlike SERMs, which only block ER activity, SERDs lead to the complete degradation of the receptor, providing a more comprehensive approach to inhibiting estrogen signaling. 2. Overcoming Resistance: SERDs can be effective in patients who have developed resistance to other hormone therapies, offering a valuable option for those with advanced or metastatic disease. 3. Targeted Action: By specifically targeting the estrogen receptor, SERDs minimize the impact on other hormonal pathways, potentially reducing side effects compared to broader endocrine therapies.
