Some of the key advantages of using PDX models include: - Preservation of Tumor Heterogeneity: PDX models maintain the genetic and phenotypic diversity of the original tumors. - Clinical Relevance: They more accurately reflect patient responses to treatments. - Longitudinal Studies: Researchers can study tumor evolution and drug resistance over time. - Personalized Medicine: PDX models can be used to tailor treatments to individual patients based on the specific characteristics of their tumors.