What are the Challenges Associated with Peptide Inhibitors?
Despite their advantages, peptide inhibitors face several challenges. One major issue is their stability in the bloodstream, as they are susceptible to degradation by proteases. Another challenge is their poor membrane permeability, which limits their ability to enter cells and reach intracellular targets. Advances in peptide engineering, such as the incorporation of unnatural amino acids and the use of nanoparticle delivery systems, are being explored to overcome these limitations.
