What are the Challenges Associated with shRNA Therapy?
Despite its promise, there are several challenges associated with shRNA therapy in cancer. One major challenge is the delivery of shRNA to the target cells. Effective and targeted delivery systems are crucial to avoid off-target effects and minimize toxicity. Additionally, there is the risk of immune responses against viral vectors used for shRNA delivery. Another challenge is the potential for unintended gene silencing due to off-target effects, which can lead to undesirable side effects.
