The delivery of cytotoxic agents faces several challenges:
- Selective Targeting: Ensuring that the drug targets cancer cells specifically without affecting healthy cells. - Drug Resistance: Cancer cells may develop resistance to the drugs, rendering them ineffective over time. - Toxicity: High doses of cytotoxic agents can cause severe side effects, limiting the maximum tolerated dose. - Pharmacokinetics: The absorption, distribution, metabolism, and excretion of the drug can vary between patients, affecting efficacy.
