What Are the Challenges in Developing CAF Inhibitors?
While CAF inhibitors hold promise, their development faces several challenges:
1. Heterogeneity of CAFs: CAFs are a diverse population of cells with varying functions, making it difficult to target them uniformly. 2. Potential Side Effects: Inhibiting CAFs can disrupt normal tissue homeostasis, leading to adverse effects. 3. Drug Resistance: Tumors may develop resistance to CAF inhibitors over time, necessitating the development of combination therapies.