What Are the Challenges in Nonclinical Evaluation?
One of the main challenges in nonclinical evaluation is the translation of findings from animal models to humans. Differences in drug metabolism, immune responses, and tumor biology between species can complicate this process. Additionally, the development of reliable and predictive preclinical models that accurately mimic human cancer remains a significant hurdle. Ethical considerations and regulatory requirements also add to the complexity of nonclinical evaluation.
