Despite its potential, SDT faces several challenges:
Sonosensitizer Development: Finding effective and safe sonosensitizers that can selectively accumulate in cancer cells remains a significant challenge. Ultrasound Parameters: Optimizing ultrasound frequency, intensity, and duration to maximize therapeutic effects while minimizing damage to surrounding tissues is crucial. Clinical Trials: More extensive clinical trials are needed to establish the efficacy and safety of SDT in a wider range of cancers. Cost: The development and implementation of SDT can be expensive, which may limit its accessibility.
