What Are the Challenges in Targeting Anti-Apoptotic Proteins?
While targeting anti-apoptotic proteins offers significant therapeutic potential, several challenges remain. One major challenge is the redundancy and compensatory mechanisms within the Bcl-2 family. For instance, inhibition of Bcl-2 might lead to upregulation of Bcl-xL or Mcl-1, allowing cancer cells to escape apoptosis. Additionally, the development of drug resistance and potential toxicity to normal cells are concerns that need to be addressed in designing effective therapies.
