What are the Challenges in Targeting Antioxidant Enzymes?
One of the main challenges is the dual role of antioxidant enzymes in both protecting normal cells and potentially aiding cancer cell survival. Another issue is the heterogeneity of tumors, as different cancers may have varying levels of antioxidant enzyme activity, requiring tailored therapeutic approaches. Moreover, the long-term effects of manipulating these enzymes are not fully understood, necessitating further research.
