What Are the Challenges in Targeting Exonucleases?
One of the main challenges in targeting exonucleases is the potential for off-target effects, as these enzymes are essential for normal cellular function. Inhibiting exonucleases in normal cells could lead to unwanted side effects, such as increased genomic instability and the risk of secondary malignancies. Therefore, developing selective inhibitors that specifically target cancer cells with exonuclease mutations is crucial.
