What are the Challenges in Targeting Gene Silencing?
Despite its potential, targeting gene silencing in cancer presents several challenges:
1. Specificity: Ensuring that therapies specifically target silenced tumor suppressor genes without affecting other genes is crucial. 2. Resistance: Cancer cells can develop resistance to therapies that target gene silencing, necessitating the development of combination therapies. 3. Delivery: Efficiently delivering epigenetic drugs to tumor cells remains a significant hurdle.
