What are the Challenges in Targeting Histone Modifications?
Despite the potential, there are several challenges in targeting histone modifications for cancer therapy. One major challenge is the lack of specificity, as these modifications are widespread and affect numerous genes. This can lead to off-target effects and toxicity. Additionally, the redundancy and compensatory mechanisms within the histone modification network can undermine the efficacy of these therapies. More research is needed to develop highly specific and effective agents.
