What are the Challenges in Targeting IGF Signaling?
Despite the potential benefits, targeting IGF signaling in cancer therapy presents several challenges. One major issue is the redundancy and complexity of the IGF signaling network, which can activate multiple pathways to promote tumor growth. Additionally, IGFs play essential roles in normal physiology, so systemic inhibition could lead to adverse effects. Balancing efficacy and safety remains a critical challenge in the development of IGF-targeted therapies.
