What Are the Challenges in Targeting Metabolic Enzymes?
While targeting metabolic enzymes holds promise, several challenges remain:
Tumor heterogeneity: Different cancer types and even different cells within the same tumor may rely on various metabolic pathways. Toxicity: Metabolic enzymes are also crucial for normal cells, so inhibitors must be selective to avoid significant side effects. Resistance: Cancer cells can adapt to metabolic stress, potentially leading to resistance against therapies targeting metabolic enzymes.
