One of the primary challenges in targeting MYC is its "undruggable" nature. MYC is a transcription factor that lacks specific enzymatic activity, making it difficult to develop inhibitors that can bind effectively. Additionally, MYC is involved in numerous cellular processes, so inhibiting it can cause significant off-target effects. Researchers are actively exploring innovative approaches to overcome these challenges, such as targeting MYC's interactions with other proteins or its downstream effectors.
