What are the Challenges in Targeting New Drug Targets?
While the identification of new targets offers promising therapeutic avenues, several challenges exist:
Drug Resistance: Cancer cells can develop resistance to targeted therapies, necessitating combination treatments or new drugs. Tumor Heterogeneity: The genetic diversity within tumors can make it difficult to target all cancer cells effectively. Off-target Effects: Ensuring that targeted therapies do not affect healthy cells is crucial for minimizing side effects. Delivery Mechanisms: Efficiently delivering drugs to the tumor site while avoiding degradation remains a significant hurdle.
