What are the Challenges in Targeting Nicotinic Receptors?
One of the main challenges in targeting nicotinic receptors is their widespread distribution in the nervous system and other tissues. This can lead to off-target effects and unintended consequences, such as disrupting normal neuronal function. Additionally, the redundancy and complexity of signaling pathways associated with nicotinic receptors can complicate the development of targeted therapies. These challenges underscore the need for more selective and specific inhibitors.
