What Are the Challenges in Targeting Nucleotide Synthesis?
One of the primary challenges in targeting nucleotide synthesis is the potential for drug resistance. Cancer cells can adapt by upregulating alternate pathways or acquiring mutations that confer resistance to inhibitors. Additionally, because nucleotide synthesis is also essential for normal cells, especially those that are rapidly dividing, there is a risk of toxicity and side effects. Therefore, a balance must be achieved between efficacy and safety in therapeutic designs.
