What Are the Challenges in Targeting the H+ Exchanger?
While targeting the H+ exchanger is a promising approach, it comes with challenges. One major issue is the potential toxicity to normal cells, as the H+ exchanger is also essential for their function. Therefore, developing selective inhibitors that specifically target cancer cells while sparing normal cells is crucial. Another challenge is understanding the different roles of various H+ exchanger isoforms in different cancer types and stages.
