What are the Challenges in Targeting Tumor Specific Antigens?
Despite their potential, there are several challenges in targeting TSAs. One major hurdle is the heterogeneity of tumors; different cells within the same tumor can express different antigens, making it difficult to find a universal target. Another challenge is immune evasion, where cancer cells downregulate antigen presentation or alter the expression of TSAs to escape immune detection. Additionally, identifying and validating TSAs for each patient is a time-consuming and costly process.
