What Are the Challenges of Drug Delivery in Cancer?
Despite advancements, drug delivery in cancer faces several challenges. These include: - Heterogeneity of Tumors: Tumors vary greatly in their biological and physical properties, making it difficult for a single delivery system to be universally effective. - Drug Resistance: Cancer cells can develop resistance to drugs, necessitating combination therapies. - Delivery Barriers: Physical barriers such as the dense extracellular matrix in tumors can impede drug penetration. - Immune System Interaction: The body's immune system can sometimes recognize and neutralize delivery vehicles, reducing their efficacy.
