What are the Clinical Implications of DNA Methylation in Cancer?
DNA methylation patterns have significant potential as biomarkers for cancer diagnosis, prognosis, and treatment. For instance, hypermethylation of the BRCA1 gene promoter is often observed in breast cancer. Moreover, drugs targeting DNMTs, such as azacitidine and decitabine, are used as therapeutic agents in certain types of cancer, including myelodysplastic syndromes and acute myeloid leukemia.
