What Are the Clinical Implications of FANCJ Mutations?
The identification of FANCJ mutations in patients can have several clinical implications. For instance, individuals with these mutations might benefit from more rigorous cancer screening programs and preventive measures. Moreover, tumors with defective FANCJ might be more sensitive to certain chemotherapeutic agents, such as platinum-based therapies and PARP inhibitors. These agents target cells with impaired DNA repair mechanisms, thus offering a potential therapeutic advantage.
