What are the Clinical Implications of TPMT Deficiency?
Individuals with TPMT deficiency have a higher risk of developing severe hematopoietic toxicity when treated with thiopurine drugs. This can lead to life-threatening complications such as severe myelosuppression and pancytopenia. Therefore, it is crucial to adjust the dosage of thiopurine drugs based on the TPMT activity to avoid these adverse effects.