What are the Clinical Implications of Tumor Suppressor Gene Mutations?
Mutations in tumor suppressor genes have significant clinical implications. They can influence the prognosis of cancer patients and affect their response to therapy. For example, cancers with p53 mutations are often more resistant to chemotherapy and radiation. Identifying these mutations can help in designing personalized treatment plans. Additionally, individuals with inherited mutations in tumor suppressor genes, such as those in BRCA1/BRCA2, may have a higher risk of developing certain cancers and can benefit from preventive measures.
