Oxaliplatin, like many chemotherapy drugs, has a range of side effects. Common side effects include peripheral neuropathy, nausea, vomiting, diarrhea, and fatigue. Peripheral neuropathy is particularly notable with oxaliplatin and can manifest as tingling, numbness, or pain in the hands and feet. This side effect can sometimes be dose-limiting, meaning it can influence the amount of the drug that a patient can safely receive.