What Are the Future Directions for Efflux Pump Inhibitors in Cancer Therapy?
Research is ongoing to develop more selective and potent efflux pump inhibitors with fewer side effects. Some promising approaches include:
Nanoparticle-based delivery: Encapsulating inhibitors in nanoparticles to target them specifically to cancer cells and reduce systemic toxicity. Combination therapies: Using efflux pump inhibitors in combination with other anticancer drugs or treatment modalities to enhance their effectiveness. Genetic approaches: Utilizing gene editing technologies like CRISPR to knock out efflux pump genes in cancer cells.
